Atg9 proteins, not so different after all

Tobacco and obesity epidemics: not so different after all?

Not so simple after all

Biologists have long thought that the internal workings of prokary­ otes—the smallest and simplest organisms, including bacteria—are well understood, and have accordingly consid­ ered eukaryotic organisms and their cells to be more fascinating objects for study. During the past decade, however, the focus of some research has begun to turn back to prokaryotes—particularly because genomic analyse...

Lysosomal and vacuolar sorting: not so different after all!

Soluble hydrolases represent the main proteins of lysosomes and vacuoles and are essential to sustain the lytic properties of these organelles typical for the eukaryotic organisms. The sorting of these proteins from ER residents and secreted proteins is controlled by highly specific receptors to avoid mislocalization and subsequent cellular damage. After binding their soluble cargo in the early...

Not so simple after all

Biologists have long thought that the internal workings of prokary­ otes—the smallest and simplest organisms, including bacteria—are well understood, and have accordingly consid­ ered eukaryotic organisms and their cells to be more fascinating objects for study. During the past decade, however, the focus of some research has begun to turn back to prokaryotes—particularly because genomic analyse...

MGUS: not so benign after all.

I t is well appreciated that persons with multiple myeloma have an increased risk of venous thrombosis. More recently, this relative risk has been shown to be increased further in these patients while on therapy with thalidomide and its derivatives. The mechanism of this increased risk for thrombosis has traditionally been attributed to traditional neoplasia risks for thrombosis, such as decrea...